Mitigation of Primary Graft Dysfunction in Lung Transplantation: Current Understanding and Hopes for the Future. (March 2020)

• Record Type: Journal Article
• Authors: Wilkey, Barbara J.; Abrams, Benjamin A.
• Is Part Of: Seminars in cardiothoracic and vascular anesthesia. Volume 24:Number 1(2020)
• Page Start: 54
• Page End: 66
• Publication Date: 2020-03
• Subjects: cardiac anesthesia -- cardiopulmonary bypass surgery -- thoracic surgery -- transplantation -- lung transplantation -- primary graft dysfunction; Cardiovascular system -- Surgery -- Methods -- Periodicals; Chest -- Surgery -- Methods -- Periodicals; Anesthesia -- Periodicals; Anesthetics -- Periodicals; Anesthesia -- Periodicals; Anesthetics -- Periodicals; Cardiovascular Surgical Procedures -- methods -- Periodicals; Thoracic Surgical Procedures -- methods -- Periodicals; 617.96
• DOI: 10.1177/1089253219881980
• Languages: English
• ISSNs: 1089-2532

Abstract

Primary graft dysfunction (PGD) is a form of acute lung injury that develops within the first 72 hours after lung transplantation. The overall incidence of PGD is estimated to be around 30%, and the 30-day mortality for grade 3 PGD around 36%. PGD is also associated with the development of bronchiolitis obliterans syndrome, a specific form of chronic lung allograft dysfunction. In this article, we will discuss perioperative strategies for PGD prevention as well as possible future avenues for prevention and treatment.