A Tumultuous Course of Exogenous Testosterone by a Bodybuilder Causing a Catastrophic Hypercoagulable State in the Surgical Intensive Care Unit. (8th December 2019)

• Record Type: Journal Article
• Authors: Lee, Kevin; Toraby, Sophia; Cotterman, Robert; Oriowo, Babatunde; Fish, John
• Other Names: Sindel Muzaffer Academic Editor.
• Is Part Of: Case reports in vascular medicine. Volume 2019(2019)
• Publication Date: 2019-12-08
• Subjects: Peripheral vascular diseases -- Periodicals; 616.13005
• DOI: 10.1155/2019/3097865
• Languages: English
• ISSNs: 2090-6986

Abstract

Abstract : Present literature demonstrates an equivocal relationship between testosterone and thrombogenicity. Herein, we describe a case in which a patient used an unspecified amount and duration of exogenous testosterone injections, subsequently developing thrombotic events in his: right radial artery, right iliac artery, superficial femoral artery, splenic artery and a bilateral lower lobe pulmonary embolism. As a result, clinicians should consider exogenous testosterone use as a potential risk factor when the etiology of a patient's thrombotic events are not clear. We also completed a literature review of the molecular mechanisms in which testosterone can increase the clot burden through an increases human platelet thromboxane A2 receptor density and an increase in erythropoiesis.