ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease. (18th December 2019)

• Record Type: Journal Article
• Authors: Wang, Zhen; Ye, Di; Ye, Jing; Wang, Menglong; Liu, Jianfang; Jiang, Huimin; Xu, Yao; Zhang, Jishou; Chen, Jiangbin; Wan, Jun
• Other Names: Mozos Ioana Guest Editor.
• Is Part Of: Disease markers. Volume 2019(2019)
• Publication Date: 2019-12-18
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2019/6129748
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : The current study demonstrates that a disintegrin and metalloproteinase with thrombospondin type 1 motif- (ADAMTS-) 5 is a key extracellular matrix protease and associated with cardiovascular diseases. However, the plasma ADAMTS-5 levels and relevance of coronary artery disease (CAD) remain largely unknown. This study is aimed at examining the relationship between the plasma ADAMTS-5 levels and the severity of coronary stenosis in patients with CAD. In the present study, the expression of ADAMTS-5 was analyzed in coronary artery samples and blood. The results showed that the plasma ADAMTS-5 levels were lower in the CAD group than in the control group. In addition, significantly higher matrix metalloproteinase- (MMP-) 2 and MMP-9 levels were also observed in the patients with CAD, and the ADAMTS-5 levels were negatively correlated with the MMP-2 and MMP-9 levels. Spearman's correlation analysis showed that the Gensini score was negatively correlated with the ADAMTS-5 levels but was positively correlated with the MMP-2 and MMP-9 levels. Receiver-operating characteristic (ROC) analysis revealed that ADAMTS-5, MMP-2, and MMP-9 may have a certain diagnostic value in CAD and that the combination of all three metalloproteinases had a higher diagnostic value. The findings provided a better understanding of the role of ADAMTS-5 in the diagnosis of CAD.