Home Environment as a Source of Life-Threatening Azole-Resistant Aspergillus fumigatus in Immunocompromised Patients. (28th September 2016)

• Record Type: Journal Article
• Authors: Lavergne, Rose-Anne; Chouaki, Taieb; Hagen, Ferry; Toublanc, Bénédicte; Dupont, Hervé; Jounieaux, Vincent; Meis, Jacques F.; Morio, Florent; Le Pape, Patrice
• Is Part Of: Clinical infectious diseases. Volume 64:Number 1(2017)
• Page Start: 76
• Page End: 78
• Publication Date: 2016-09-28
• Subjects: Aspergillus fumigatus -- azole resistance -- TR46/Y121F/T289A -- environment -- invasive aspergillosis; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciw664
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract : A case of fatal aspergillosis due to a TR46 /Y121F/T289A azole-resistant Aspergillus fumigatus is reported. Environmental investigations at the patient's residence led to the recovery of TR46 /Y121F/T289A isolates, genotypically indistinguishable from the clinical isolate, supporting for the first time the direct role of household as potential source of azole-resistant invasive aspergillosis.