Electrochemical intramolecular C–H/N–H functionalization for the synthesis of isoxazolidine-fused isoquinolin-1(2H)-ones. Issue 1 (3rd December 2019)

• Record Type: Journal Article
• Authors: Zhang, Lin-Bao; Geng, Rui-Sen; Wang, Zi-Chen; Ren, Guang-Yi; Wen, Li-Rong; Li, Ming
• Is Part Of: Green chemistry. Volume 22:Issue 1(2020)
• Page Start: 16
• Page End: 21
• Publication Date: 2019-12-03
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc03290h
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A general and practical protocol for the construction of isoxazolidine-fused isoquinolin-1(2 H )-ones has been described by electrochemical-oxidation-induced intramolecular annulation via amidyl radicals. Abstract : A general and practical protocol for the construction of isoxazolidine-fused isoquinolin-1(2 H )-ones has been described by electrochemical-oxidation-induced intramolecular annulation via amidyl radicals. In an undivided cell, isoquinolinones could be easily generated from various available amides bearing CONHOR groups under metal-free, additive-free and external oxidant-free conditions. Moreover, this transformation proceeded smoothly by using cheap 95% ethanol as the green solvent and could be extended to the gram scale.