Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors. Issue 3 (12th December 2019)

• Record Type: Journal Article
• Authors: Kimura, Yasuaki; Shu, Zhaoma; Ito, Mika; Abe, Naoko; Nakamoto, Kosuke; Tomoike, Fumiaki; Shuto, Satoshi; Ito, Yoshihiro; Abe, Hiroshi
• Is Part Of: Chemical communications. Volume 56:Issue 3(2020)
• Page Start: 466
• Page End: 469
• Publication Date: 2019-12-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04872c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We herein report a new approach for RNA interference, so-called "build-up RNAi" approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. Abstract : We herein report a new approach for RNA interference, so-called "build-up RNAi" approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The advantages of using these circular RNA formats for RNAi were presented in aspects of immunogenicity and cellular uptake.