Convenient synthesis of phosphinecarboxamide and phosphinecarbothioamide by hydrophosphination of isocyanates and isothiocyanates. Issue 3 (11th December 2019)

• Record Type: Journal Article
• Authors: Itazaki, Masumi; Matsutani, Takanari; Nochida, Tomoya; Moriuchi, Toshiyuki; Nakazawa, Hiroshi
• Is Part Of: Chemical communications. Volume 56:Issue 3(2020)
• Page Start: 443
• Page End: 445
• Publication Date: 2019-12-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08329d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Convenient synthesis of phosphinecarboxamidein by hydrophosphination of isocyanates (and isothiocyanates) was achieved without catalyst and solvent. This system shows shorter reaction time, high yield, and good functional group tolerance. Abstract : Reactions of isocyanates with primary and secondary phosphines without solvent at room temperature afforded the corresponding phosphinecarboxamide (RN(H)COPR′2 ) in excellent yields. This reaction system is applicable for isothiocyanates. The compounds newly obtained were fully characterized using multielement NMR spectroscopy. In addition, the molecular structure of Cl(CH2 )2 N(H)COPPh2 was studied by single-crystal X-ray diffraction.