The acidic hydrolysis of N-acetylneuraminic 4, 5-oxazoline allows a direct functionalization of the C5 position of Neu5Ac2en (DANA). Issue 1 (24th December 2019)
- Record Type:
- Journal Article
- Title:
- The acidic hydrolysis of N-acetylneuraminic 4, 5-oxazoline allows a direct functionalization of the C5 position of Neu5Ac2en (DANA). Issue 1 (24th December 2019)
- Main Title:
- The acidic hydrolysis of N-acetylneuraminic 4, 5-oxazoline allows a direct functionalization of the C5 position of Neu5Ac2en (DANA)
- Authors:
- Rota, Paola
La Rocca, Paolo
Cirillo, Federica
Piccoli, Marco
Allevi, Pietro
Anastasia, Luigi - Abstract:
- Abstract : The Neu5Ac 4, 5-oxazoline ring-opening allows the direct generation of a free C5-amino group key to synthesize antiviral drugs. Abstract : The acidic hydrolysis of N -acetylneuraminic 4, 5-oxazoline affords the corresponding 2, 3-unsaturated amino ester, which was not previously detected (nor isolated) due to the unexpected rearrangement into its corresponding alcohol. In this work, we unveiled the mechanism of these reactions and optimized the conditions to obtain either synthetic intermediate.
- Is Part Of:
- RSC advances. Volume 10:Issue 1(2020)
- Journal:
- RSC advances
- Issue:
- Volume 10:Issue 1(2020)
- Issue Display:
- Volume 10, Issue 1 (2020)
- Year:
- 2020
- Volume:
- 10
- Issue:
- 1
- Issue Sort Value:
- 2020-0010-0001-0000
- Page Start:
- 162
- Page End:
- 165
- Publication Date:
- 2019-12-24
- Subjects:
- Chemistry -- Periodicals
540.5 - Journal URLs:
- http://pubs.rsc.org/en/Journals/JournalIssues/RA ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c9ra10215a ↗
- Languages:
- English
- ISSNs:
- 2046-2069
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 8036.750300
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 12568.xml