A polyesteramide library from dicarboxylic acids and 2, 2′-bis(2-oxazoline): synthesis, characterization, nanoparticle formulation and molecular dynamics simulations. Issue 1 (2nd December 2019)

• Record Type: Journal Article
• Authors: Muljajew, Irina; Erlebach, Andreas; Weber, Christine; Buchheim, Johannes R.; Sierka, Marek; Schubert, Ulrich S.
• Is Part Of: Polymer chemistry. Volume 11:Issue 1(2020)
• Page Start: 112
• Page End: 124
• Publication Date: 2019-12-02
• Subjects: Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.705
• DOI: 10.1039/c9py01293a
• Languages: English
• ISSNs: 1759-9954

Abstract

Abstract : A combined experimental and in silico approach enabled tailoring of polyesteramides with respect to formation of aqueous nanoparticle dispersions. Abstract : The step growth polyaddition of a variety of dicarboxylic acids and 2, 2′-bis(2-oxazoline) enabled access to a library of polyesteramides (PEA) with different linker lengths or bulkiness. PEA with alkylene spacers represented semicrystalline materials due to hydrogen bond formation between the oxamide moieties, as is evident from dynamic scanning calorimetry and wide-angle X-ray scattering (145 °C < T m < 225 °C). In contrast, PEAs comprising substituted spacers resulted in amorphous materials suitable for the preparation of nanoparticle dispersions by means of direct nanoprecipitation from hexafluoroisopropanol into water. Strong intermolecular interactions that were evident from Hildebrand solubility parameters δ resulted in the formation of aggregates for the semi-crystalline materials. Although Hildebrand parameters alone provided less accurate solubility predictions of the PEAs in acetone and THF, the Flory–Huggins parameters χ PS revealed pronounced changes of intermolecular interactions with variation of the polymer structure, clearly demonstrating a tunable hydrophobicity of the synthesized PEAs.