Long-term mortality rate for cardiovascular disease in 656 chronic myeloid leukaemia patients treated with second- and third-generation tyrosine kinase inhibitors. (15th February 2020)

• Record Type: Journal Article
• Authors: Caocci, Giovanni; Mulas, Olga; Annunziata, Mario; Luciano, Luigiana; Abruzzese, Elisabetta; Bonifacio, Massimiliano; Orlandi, Ester Maria; Albano, Francesco; Galimberti, Sara; Iurlo, Alessandra; Pregno, Patrizia; Sgherza, Nicola; Martino, Bruno; Binotto, Gianni; Castagnetti, Fausto; Gozzini, Antonella; Bocchia, Monica; Fozza, Claudio; Stagno, Fabio; Simula, Maria Pina; De Gregorio, Fiorenza; Trawinska, Malgorzata Monika; Scaffidi, Luigi; Elena, Chiara; Attolico, Imma; Baratè, Claudia; Cattaneo, Daniele; Pirillo, Francesca; Gugliotta, Gabriele; Sicuranza, Anna; Molica, Matteo; La Nasa, Giorgio; Foà, Robin; Breccia, Massimo;
• Is Part Of: International journal of cardiology. Volume 301(2020)
• Page Start: 163
• Page End: 166
• Publication Date: 2020-02-15
• Subjects: Chronic myeloid leuk -- a -- emia -- Cardiovascular toxicity -- TKI -- Ischemic heart disease; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2019.10.036
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: Limited information is available regarding the rate of long-term cardiovascular (CV) mortality in chronic myeloid leukaemia (CML) patients treated with second- and third-generation tyrosine kinase inhibitors (2 ndG /3 rdG TKIs) in the real-life practice. Methods: We identified 656 consecutive CML patients treated with nilotinib, dasatinib, bosutinib and ponatinib. Results: The 15-year CV-mortality free survival was 93 ± 2.8%. Age ≥65 years (p = 0.005) and a positive history of CV disease (p = 0.04) were significantly associated with a lower CV-mortality free survival. CV disease accounted for 16.5% and 5% of potential years of life lost (PYLL) in male and female patients, respectively. The standard mortality ratio (SMR) following ischemic heart disease (IHD) was 3.9 in males and 3.8 in female patients, meaning an excess of IHD deaths observed, in comparison with the population of control. Conclusion . Prevention strategies based on CV risk factors, in particular in those patients with a previous history of CV disease, should be considered. Highlights: Limited information is available on the CV mortality rate in patients with CML. Age over 65 and a previous CV disease were correlated with a worse CV-free survival. The contribution of CV disease to PYLL in CML was not higher than in the controls. IHD determined a SMR greater than expected in a standard population.