Non-O blood group thrombotic thrombocytopenic purpura patients take longer to recover as measured by number of therapeutic plasma exchanges needed for platelet recovery. Issue 185 (January 2020)

• Record Type: Journal Article
• Authors: Behtaj, Mohadese; Zhu, Meng-Lei; Bittencourt, Cassiana E.; Ha, Jennifer P.; Maitta, Robert W.
• Is Part Of: Thrombosis research. Issue 185(2020)
• Page Start: 78
• Page End: 84
• Publication Date: 2020-01
• Subjects: ABO blood group -- Therapeutic plasma exchange -- Thrombotic thrombocytopenic purpura -- ADAMTS13; TPE therapeutic plasma exchange -- TTP thrombotic thrombocytopenic purpura -- NoP number of TPE procedures -- UL ultra large -- vWF von Willebrand factor -- BMI body mass index; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2019.11.022
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Introduction: Therapeutic plasma exchange (TPE) is mainstay therapy for thrombotic thrombocytopenic purpura (TTP). However, it remains controversial if ABO type influences diagnosis or time to remission. Materials and methods: We investigated if ABO type influences length of TPE regimen in TTP patients with ADAMTS13 deficiency at our institution. Seventy out of 71 patients with suspected TTP who had ADAMTS13 activity measured were included. ADAMTS13 activity <10% defined those with idiopathic/acquired TTP (41/70). Results: We found that among patients with ADAMTS13 deficiency, non-O patients required a significantly greater number of TPE (NoP) compared to O patients ( p = 0.039). Additionally, patients with ADAMTS13 deficiency regardless of ABO type needed more TPE to achieve platelet recovery compared to those patients without deficiency ( p = 0.00002). In regard to other variables that may affect response to therapy in TTP patients, we found no association between obesity and NoP; however, obesity rate was higher among ADAMTS13 deficient patients compared to overall obesity rate of our regional general population. Likewise, were found that blood group O did not occur with greater frequency in our cohort. Conclusions: Our data indicates that ABO may affect the NoP patients required for disease remission. We found that non-O patients needed more procedures to overcome their disease. Further work with greater number of patients will be needed to determine if specific non-O blood types require more procedures to recover their platelet count. Highlights: Non-O blood group TTP patients needed more procedures to recover from disease. ADAMTS13 deficient patients regardless of ABO group needed more TPE to achieve platelet recovery. Obesity rate was higher in ADAMTS13 deficient patients compared to regional population.