Prevalence and time trend analysis of antimicrobial resistance in respiratory bacterial pathogens collected from diseased pigs in USA between 2006–2016. (February 2020)

• Record Type: Journal Article
• Authors: Hayer, Shivdeep Singh; Rovira, Albert; Olsen, Karen; Johnson, Timothy J.; Vannucci, Fabio; Rendahl, Aaron; Perez, Andres; Alvarez, Julio
• Is Part Of: Research in veterinary science. Volume 128(2020)
• Page Start: 135
• Page End: 144
• Publication Date: 2020-02
• Subjects: Antimicrobial resistance -- Pigs -- Swine respiratory pathogens -- Surveillance; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2019.11.010
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: Swine respiratory disease complex (SRDC) causes massive economic losses to the swine industry and is a major animal welfare concern. Antimicrobials are mainstay in treatment and control of SRDC. However, there is a lack of data on the prevalence and trends in resistance to antimicrobials in bacterial pathogens associated with SRDC. The objective of this study was to estimate the prevalence and changes in resistance to 13 antimicrobials in swine bacterial pathogens ( Streptococcus suis, Pasteurella multocida, Actinobacillus suis and Haemophilus parasuis ) in the U.S.A using data collected at University of Minnesota Veterinary Diagnostic Laboratory between 2006 and 2016. For antimicrobials for which breakpoints were available, prevalence of resistance remained below 10% except for tetracycline in S. suis and P. multocida isolates, and these prevalence estimates remained consistently low over the years despite statistical significance ( p < .05) in trend analysis. For antimicrobial-bacterial combinations without available breakpoints, the odds of isolates being resistant increased by >10% annually for 7 and 1 antimicrobials in H. parasuis and S. suis isolates respectively, and decreased >10% annually for 4 and 1 antimicrobials in A. suis and H. parasuis isolates, respectively, according to the ordinal regression models. Clinical implications of changes in AMR for A. suis and H. parasuis should be interpreted cautiously due to the lack of interpretive criteria and challenges in antimicrobial susceptibility tests in the case of H. parasuis . Future studies should focus on surveillance of antimicrobial resistance and establishment of standardized susceptibility testing methodologies and interpretive criteria for these animal pathogens of critical importance. Highlights: AMR data for bacterial swine pathogens associated with SDRC are lacking AMR data on swine bacterial pathogens collected over 11 years in the U.S.A was analyzed for changes in AMR prevalence AMR in S. suis and P. multocida isolates mostly remained low. There were statistically significant changes in AMR in A. suis and H. parasuis Use of surrogate breakpoints can lead to different AMR estimates for certain bacteria