Maternal bisphenol and phthalate urine concentrations and weight gain during pregnancy. (February 2020)

• Record Type: Journal Article
• Authors: Philips, Elise M.; Santos, Susana; Steegers, Eric A.P.; Asimakopoulos, Alexandros G.; Kannan, Kurunthachalam; Trasande, Leonardo; Jaddoe, Vincent W.V.
• Is Part Of: Environment international. Volume 135(2020)
• Publication Date: 2020-02
• Subjects: Bisphenol -- Phthalate -- Gestational weight gain -- Cohort studies; BPA bisphenol A -- BPF bisphenol F -- BPS bisphenol S -- DDE dichlorodiphenyl dichloroethene -- DEHP Di-2-ethylhexylphthalate -- DNOP di-n-octylphthalate -- FFQ food-frequency questionnaire -- GWG gestational weight gain -- HCHs hexachlorocyclohexanes -- HMW high molecular weight -- IQR inter-quartile range -- LMW low molecular weight -- mCPP mono)3-carboxypropyl) phthalate -- MEP mono-ethyl phthalate -- mHpP mono-2-heptylphthalate -- mHxP mono-hexylphthalate -- PA phthalic acid -- PBDEs polybrominated diphenyl ethers -- PCBs polychlorinated bisphenyls -- PFASs perfluoroalkyl substances -- PFOS perfluorooctanesulfonate -- POPs persistant organic pollutions; Environmental protection -- Periodicals; Environmental health -- Periodicals; Environmental monitoring -- Periodicals; Environmental Monitoring -- Periodicals; Environnement -- Protection -- Périodiques; Hygiène du milieu -- Périodiques; Environnement -- Surveillance -- Périodiques; Environmental health; Environmental monitoring; Environmental protection; Periodicals; 333.705
• DOI: 10.1016/j.envint.2019.105342
• Languages: English
• ISSNs: 0160-4120

Abstract

Highlights: We assess the associations of bisphenols and phthalates with gestational weight gain. Bisphenol S was associated with lower gestational weight gain in normal weight women. The strongest reduction in weight gain was observed for mid-to-late pregnancy. Early pregnancy bisphenols may lead to reduced weight in second half of pregnancy. Abstract: Background: Insufficient or excessive gestational weight gain are associated with increased risks of adverse birth and childhood outcomes. Increasing evidence suggests that exposure to bisphenols and phthalates may disrupt hormonal pathways and thereby influence gestational weight gain. Objective: To examine the associations of early and mid-pregnancy bisphenol and phthalate urine concentrations with gestational weight gain. Methods: In a population-based prospective cohort study among 1, 213 pregnant women, we measured early and mid-pregnancy bisphenol and phthalate urine concentrations. Maternal anthropometrics before pregnancy were obtained by questionnaire and repeatedly measured at our research center during pregnancy. We used linear and logistic regressions to evaluate the associations of bisphenols and phthalates with total and period-specific gestational weight gain. Results: Higher maternal total bisphenols and bisphenol S were associated with a lower total gestational weight gain at nominal level. Stratification by body mass index group showed that higher total bisphenols and bisphenol S were associated with lower total gestational weight gain specifically in normal weight women (respectively −509 g [95% CI −819, −198] and −398 g [95% CI −627, −169]). Each log unit increase in early pregnancy total bisphenol and bisphenol A urine concentrations were associated with lower mid- to late pregnancy gestational weight gain in the whole group (effect estimates −218 g/log unit increase [95% CI −334, −102] and −132 g/log unit increase [95% CI −231, −34], respectively). These associations were independent of mid-pregnancy compounds. Mid-pregnancy bisphenols and phthalates concentrations were not associated with gestational weight gain. Discussion: Higher maternal bisphenol urine concentrations in early pregnancy may lead to reduced gestational weight in second half of pregnancy. Further research is needed to assess the effects of maternal bisphenols and phthalates urine concentrations on placental and fetal growth and development.