Antibodies against nephronectin ameliorate anti‐type II collagen‐induced arthritis in mice. Issue 1 (24th November 2019)

• Record Type: Journal Article
• Authors: Kon, Shigeyuki; Honda, Machiko; Ishikawa, Kiyoshi; Maeda, Masahiro; Segawa, Tatsuya
• Is Part Of: FEBS open bio. Volume 10:Issue 1(2020)
• Page Start: 107
• Page End: 117
• Publication Date: 2019-11-24
• Subjects: antibody -- anti‐type II collagen‐induced arthritis -- autoimmune diseases -- ELISA -- nephronectin; Molecular biology -- Periodicals; Cytology -- Periodicals; Life sciences -- Periodicals; Biological Science Disciplines -- Periodicals; Molecular Biology -- Periodicals; Cell Biology -- Periodicals; Cytology; Life sciences; Molecular biology; Periodicals; 572.805
• DOI: 10.1002/2211-5463.12758
• Languages: English
• ISSNs: 2211-5463

Abstract

Abstract : The extracellular matrix protein nephronectin (Npnt) is known to be critical for kidney development, but its function in inflammatory diseases is unknown. Here, we developed a new enzyme‐linked immunosorbent assay system to detect Npnt in various autoimmune diseases, which revealed that plasma Npnt levels are increased in various mouse autoimmune models. We also report that antibodies against the α8β1 integrin‐binding region of Npnt protect mice from anti‐type II collagen‐induced arthritis, suggesting that Npnt may be a potential therapeutic target molecule for the prevention of autoimmune arthritis. Abstract : The role of extracellular matrix protein nephronectin (Npnt) in inflammatory diseases is unknown. In this study, we show that plasma Npnt levels are increased in various mouse autoimmune models and antibodies against the α8β1 integrin‐binding region attenuated the development of anti‐type II collagen‐induced arthritis in mice.