Anti-pseudo-allergic capacity of alkaloids screened from Uncaria rhynchophylla. (2nd December 2019)

• Record Type: Journal Article
• Authors: Xie, Yitong; Wei, Di; Hu, Tian; Hou, Yajing; Lin, Yuanyuan; He, Huaizhen; Wang, Cheng
• Is Part Of: New journal of chemistry. Volume 44:Number 1(2020)
• Page Start: 38
• Page End: 45
• Publication Date: 2019-12-02
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c9nj04551a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : Two alkaloids were screened from Uncaria rhynchophylla (UR) by MRGPRX2-HEK293/CMC model and showed anti-pseudo-allergic effects in vivo and in vitro, which may provide evidence for anti-pseudo-allergic effects and bioactivity development of UR. Abstract : Uncaria rhynchophylla (UR) is a traditional Chinese herb widely used for hyperpyrexia, epilepsy, preeclampsia, and hypertension. In this paper, the potential anti-pseudo-allergic components in UR were explored. Six alkaloids in UR possessed good retention properties on an established MRGPRX2/CMC model. Among them, isorhynchophylline (Isorhy) and corynoxeine (Cor) could inhibit the pseudo-allergic reaction induced by C48/80 both in vivo and in vitro . Therefore, this study provides evidence for the anti-pseudo-allergic effect of UR and for development of the biological activity of this genus.