Gene‐Hydrogel Microenvironments: Gene‐Hydrogel Microenvironment Regulates Extracellular Matrix Metabolism Balance in Nucleus Pulposus (Adv. Sci. 1/2020). Issue 1 (8th January 2020)

• Record Type: Journal Article
• Authors: Chen, Wei; Chen, Hao; Zheng, Dandan; Zhang, Hongbo; Deng, Lianfu; Cui, Wenguo; Zhang, Yuhui; Santos, Hélder A.; Shen, Hongxing
• Is Part Of: Advanced science. Volume 7:Issue 1(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-08
• Subjects: Agomir -- extracellular matrix -- gene therapy -- gene‐hydrogel microenvironment -- hydrogels; Science -- Periodicals; 505
• DOI: 10.1002/advs.202070001
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In degenerative diseases, microenvironment deterioration is often followed by a vicious circle of cell death and aggravation of microenvironment deterioration. To break the cycle, a gene‐hydrogel microenvironment is constructed in article number 1902099 by Yuhui Zhang, Hélder A. Santos, Hongxing Shen, and co‐workers in situ, which regulates the synthesis/catabolism balance of extracellular matrix in the nucleus pulposus of the intervertebral disc and improves the tissue microenvironment regeneration.