Ni-catalyzed 1, 2-benzylboration of 1, 2-disubstituted unactivated alkenes. Issue 47 (22nd October 2019)

• Record Type: Journal Article
• Authors: Joung, Seewon; Bergmann, Allison M.; Brown, M. Kevin
• Is Part Of: Chemical science. Volume 10:Issue 47(2019)
• Page Start: 10944
• Page End: 10947
• Publication Date: 2019-10-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc04199k
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A method for the 1, 2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochemistry. Abstract : Nickel-catalyzed 1, 2-carboboration of alkenes is emerging as a useful method for chemical synthesis. Prior studies have been limited to only the incorporation of aryl groups. In this manuscript, a method for the 1, 2-benzylboration of unactivated alkenes is presented. The reaction combines readily available alkenes, diboron reagents and benzylchlorides to generate synthetically versatile products with control of stereochemistry. The utility of the products as well as the mechanistic details of the process are also presented.