Functionalization of bioactive substrates with a F5SCH = CH moiety. (2nd January 2020)

• Record Type: Journal Article
• Authors: Brel, Valery K.; Artyushin, Oleg I.; Moiseeva, Aleksandra A.; Sharova, Elena V.; Buyanovskaya, Anastasiya G.; Nelyubina, Yulia V.
• Is Part Of: Journal of sulfur chemistry. Volume 41:Number 1(2020)
• Page Start: 29
• Page End: 43
• Publication Date: 2020-01-02
• Subjects: Fluorosulfanylvinyl derivatives -- daunorubicin -- cytisine -- camphecene -- click reactions; Sulfur -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.72305
• DOI: 10.1080/17415993.2019.1662906
• Languages: English
• ISSNs: 1741-5993

Abstract

ABSTRACT: A convenient approach to modify bioactive substrates such as daunorubicin, cytisine, and camphecene with a pentafluorosulfanylvinyl moiety have been suggested. F5 S-CH = CH derivatives of daunorubicin were obtained by acylation with reactive 4-nitrophenyl-4-(pentafluoro-λ 6 -sulfanyl)alkenyl carbonates, while the corresponding conjugates of anthracycline antibiotic daunorubicin, alkaloid cytisine and camphecene were synthesized using a click chemistry procedure. GRAPHICAL ABSTRACT: