Evaluation of the cytotoxicity on breast cancer cell of extracts and compounds isolated from Hyptis pectinata (L.) poit. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Santana, Fernanda R.; Luna-Dulcey, Liany; Antunes, Víctor U.; Tormena, Claudio F.; Cominetti, Marcia R.; Duarte, Marcelo C.; da Silva, James A.
• Is Part Of: Natural product research. Volume 34:Issue 1(2020)
• Page Start: 102
• Page End: 109
• Publication Date: 2020-01-02
• Subjects: Liquid chromatography -- pectinolides -- antiproliferative activity -- synergistic effect -- cancer; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1628747
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Hyptis pectinata is a herb popularly used in Brazil for the treatment of inflammations, pain, bacterial infections and cancer. In the present study, inflorescences (MPIn), leaves (MPL), branches (MPB), root (MPR) extracts and three compounds isolated from MPIn were assayed against breast tumor cell lines. The structures of the three compounds (pectinolide J, hyptolide and pectinolide E) were determined by means of spectroscopic analysis. Pectinolide J was isolated for the first time. The MPIn, MPL and MPR exhibited specific antiproliferative activity on tumor cell lines when compared to normal cell lines with IC50 of 52.01 ± 0.64, 45.91 ± 0.02 μg/mL and 82.84 ± 0.03 μg/mL, respectively. Although the isolated substances did not present good antiproliferative activity, when the three were associated, a greater biological effect was observed, suggesting a synergistic effect. Hyptolide (5.6 ± 0.4 μg/mL) showed IC50 sufficiently low to be considered as a drug prototype. Abstract :