Fast construction of isoquinolin-1(2H)-ones by direct intramolecular C–H/N–H functionalization under metal-free conditions. Issue 2 (13th December 2019)

• Record Type: Journal Article
• Authors: Wen, Li-Rong; Ren, Guang-Yi; Geng, Rui-Sen; Zhang, Lin-Bao; Li, Ming
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 2(2019)
• Page Start: 225
• Page End: 229
• Publication Date: 2019-12-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob02430a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Polycyclic six-, seven- and eight-membered N-heterocycles can be rapidly synthesized employing PIDA under metal-free conditions within 1 min. Abstract : The general protocol for the synthesis of isoxazolidine-fused isoquinolin-1(2 H )-ones was established with the help of bench stable hypervalent iodine reagent PIDA. Polycyclic six-, seven- and eight-membered N-heterocycles can be rapidly synthesized from available amides under metal-free conditions within 1 min at room temperature through C–H/N–H functionalization. Moreover, the protocol has the merits of broad substrate scope, atom economy and operational simplicity.