Selective geranylation of biflavonoids by Aspergillus terreus aromatic prenyltransferase (AtaPT). Issue 1 (20th November 2019)

• Record Type: Journal Article
• Authors: Xu, Kangping; Yang, Can; Xu, Yuanyuan; Li, Dan; Bao, Shumin; Zou, Zhenxing; Kang, Fenghua; Tan, Guishan; Li, Shu-Ming; Yu, Xia
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 1(2019)
• Page Start: 28
• Page End: 31
• Publication Date: 2019-11-20
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob02296a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Regio-selective geranylation of natural biflavonoids using Aspergillus terreus aromatic prenyltransferase (AtaPT) as an efficient catalyst. Abstract : Prenylation increases the bioactivity of flavonoids. Herein, we report the first examples of regioselective enzymatic geranylation of biflavonoids using Aspergillus terreus aromatic prenyltransferase (AtaPT). For biflavonoids 1–3 dimerized through a diphenyl linkage, geranylation occurs at the hydrogen bond involving C5′′–OH group, which is less chemically accessible than other OH groups in the molecule. This study would be referential for developing green synthetic solutions for prenylated biflavonoids.