A coumarin chalcone ratiometric fluorescent probe for hydrazine based on deprotection, addition and subsequent cyclization mechanism. Issue 99 (28th November 2019)

• Record Type: Journal Article
• Authors: Xing, Miaomiao; Wang, Kangnan; Wu, Xiangwen; Ma, Shuyue; Cao, Duxia; Guan, Ruifang; Liu, Zhiqiang
• Is Part Of: Chemical communications. Volume 55:Issue 99(2019)
• Page Start: 14980
• Page End: 14983
• Publication Date: 2019-11-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc08174g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A coumarin chalcone derivative with a levulinic acid terminal group acts as a ratiometric fluorescent probe for hydrazine based on deprotection, addition and a subsequent cyclization reaction mechanism. Abstract : A ratiometric fluorescent probe for hydrazine based on a coumarin chalcone framework and a levulinic acid terminal group with a low detection limit (0.1 ppb, 0.003 μM), a large ratiometric fluorescence change ( I 465 / I 575, 1265-fold enhancement) and a wide pH work range (3.0–12.0) was developed. The mechanism analysis of the isolated hydrazine product characterized by NMR, HRMS and the crystal structure indicates that the levulinic acid group is firstly removed by deprotection and then the dihydropyrazole ring is formed due to the addition and subsequent cyclization reaction in the presence of hydrazine.