Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation. Issue 24 (20th November 2019)

• Record Type: Journal Article
• Authors: Dao, Pham Duy Quang; Lim, Ho-Jin; Cho, Chan Sik
• Is Part Of: Green chemistry. Volume 21:Issue 24(2019)
• Page Start: 6590
• Page End: 6593
• Publication Date: 2019-11-20
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/c9gc03410b
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A green construction of trinuclear N-fused hybrid scaffolds by transition metal-free double C(sp 2 )–N coupling of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles under microwave irradiation has been developed. Abstract : Treatment of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles in the presence of a base under microwave irradiation triggers double C(sp 2 )–N coupling to form trinuclear N-fused hybrid scaffolds. A reaction pathway involving nucleophilic aromatic substitution (SN Ar) accompanied by ammonia evolution is proposed as a key step of this transition metal-free process.