Eupulcherol A, a triterpenoid with a new carbon skeleton from Euphorbia pulcherrima, and its anti-Alzheimer's disease bioactivity. Issue 1 (27th November 2019)

• Record Type: Journal Article
• Authors: Yu, Chun-Xue; Wang, Ru-Yue; Qi, Feng-Ming; Su, Pan-Jie; Yu, Yi-Fan; Li, Bing; Zhao, Ye; Zhi, De-Juan; Zhang, Zhan-Xin; Fei, Dong-Qing
• Is Part Of: Organic & biomolecular chemistry. Volume 18:Issue 1(2019)
• Page Start: 76
• Page End: 80
• Publication Date: 2019-11-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob02334h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Eupulcherol A (1 ), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima . Abstract : Eupulcherol A (1 ), a novel triterpenoid with an unprecedented carbon skeleton, was isolated from Euphorbia pulcherrima . Its structure was determined by comprehensive analysis of spectroscopic data, including HRESIMS and 1D and 2D NMR, and the absolute configuration was defined by single crystal X-ray diffraction analysis. Biological studies showed that compound 1 possessed anti-Alzheimer's disease (AD) bioactivity, which could delay paralysis of transgenic AD Caenorhabditis elegans . A plausible biogenetic pathway for eupulcherol A (1 ) was also proposed.