Associations of urinary phthalate metabolites with risk of papillary thyroid cancer. (February 2020)

• Record Type: Journal Article
• Authors: Miao, Hongjian; Liu, Xin; Li, Jingguang; Zhang, Lei; Zhao, Yunfeng; Liu, Shaoyan; Ni, Song; Wu, Yongning
• Is Part Of: Chemosphere. Volume 241(2020)
• Publication Date: 2020-02
• Subjects: Thyroid cancer -- Case-control study -- Phthalate -- Urinary metabolites; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.125093
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Some studies have revealed thyrotoxicity of phthalates; however, associations of phthalate exposure with papillary thyroid cancer (PTC) remain unclear. We conducted a pair-matching case-control study of 111 PTC cases and 111 age- and sex-matched non-PTC controls to examine associations between urinary concentrations of phthalate metabolites and PTC. Phthalate metabolites were determined in fasting urine specimens by ultra-performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS). After adjusting for potential confounders and other phthalate metabolites, the concentrations of the sum of di (2-ethylhexly) phthalate (DEHP) metabolites in urine were positively associated with PTC [odds ratio (OR) = 5.35; 95% confidence interval (CI): 1.61–17.83], suggesting the effect of phthalates exposure on PTC development. The findings require confirmation. Graphical abstract: Image 1 Highlights: Associations of urinary phthalate metabolites with PTC risk were examined. DEHP metabolites were positively associated with increased risk of PTC. The associations were influenced by urinary iodine levels.