Copper(I) catalysed direct synthesis of 2-methylene-4-chromanols. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Sarkar, Debayan; Behera, Sagarika
• Is Part Of: Tetrahedron letters. Volume 61:Issue 1(2020)
• Publication Date: 2020-01-02
• Subjects: Chromanols -- Chromanols -- Catalysis -- Annulation -- Atom economic; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.151341
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Copper Catalysed atom-economic synthesis of 2-methylene chromanols. The reaction is an open flask reaction. No external ligand is necessary for this transformation. Satisfactory yields with di-halides and unprotected alcohols. Abstract: A copper catalyzed atom-economic synthesis of 2-methylene-4-chromanols has been described. The 2-methylene-4-chromanols act as an important entry points to a large section of biologically active motifs. The reaction delivers a wide substrate scope with moderate to excellent yields with substituted alkynes and in presence of unprotected alcoholic functionalities to deliver the 2-(2-hydroxy alkylidene)chroman-4-ols.