Association between intraplaque neovascularization assessed by contrast-enhanced ultrasound and the risk of stroke. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Song, Y.; Dang, Y.; Dang, L.L.; Zhao, C.; Zheng, J.; Feng, J.; Ruan, L.T.
• Is Part Of: Clinical radiology. Volume 75:Issue 1(2020)
• Page Start: 70
• Page End: 75
• Publication Date: 2020-01
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2019.08.019
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : AIM: To determine the cut-off value of the area ratio under the curve (ARUC) for predicting symptoms of stroke. MATERIALS AND METHODS: Contrast-enhanced ultrasound was used to analyse intraplaque neovascularization (IPN). The correlations between the ARUC and risk factors of stroke were examined. A receiver operating characteristic curve was used to determine the cut-off value of the ARUC. RESULTS: Using a quantitative analysis method for IPN, the ARUC was significantly higher in the symptomatic group than in the asymptomatic group ( p= 0.017). The ARUC was positively associated with the homocysteine level ( r= 0.429, p= 0.002) and high-sensitivity C-reactive protein level ( r= 0.424, p= 0.003). Regression analysis showed that the ARUC was a risk factor for symptoms of stroke. The receiver operating characteristic curve showed that the cut-off value for symptoms was 0.24; the sensitivity was 77%, and the specificity was 70%; the positive predictive value was 68%, and the negative predictive value was 78%. CONCLUSION: IPN was a risk factor for the occurrence of the clinical symptoms of stroke. Patients with an ARUC of >0.24 had a higher risk of stroke. Highlights: IPN as assessed by CEUS was positively correlated with inflammation. ARUC was a risk factor for symptoms of stroke. An ARUC of >0.24 was associated with a higher risk of symptoms of stroke.