A New Host Factor Essential for Chikungunya Virus. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Schnierle, Barbara S.
• Is Part Of: Trends in microbiology. Volume 28:Issue 1(2020)
• Page Start: 2
• Page End: 4
• Publication Date: 2020-01
• Subjects: FHL1 -- chikungunya virus -- non-structural protein 3 -- alphavirus; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2019.11.002
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : FHL1 has been identified as a host protein that is essential for chikungunya virus (CHIKV) replication. FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex. Inhibition of this interaction is a promising target for drug development.