Diaphragm muscle adaptations in health and disease. (2019)

• Record Type: Journal Article
• Authors: Fogarty, Matthew J.; Sieck, Gary C.
• Is Part Of: Drug discovery today. Volume 29/30(2019)
• Page Start: 43
• Page End: 52
• Publication Date: 2019
• Subjects: Drug development -- Periodicals; Physiology, Pathological -- Periodicals; Drugs -- Testing -- Periodicals; Diseases -- Animal models -- Evaluation -- Periodicals; 616.027
• DOI: 10.1016/j.ddmod.2019.10.002
• Languages: English
• ISSNs: 1740-6757

Abstract

Abstract : Breathing is achieved without thought despite being controlled by a complex neural network. The diaphragm is the predominant muscle responsible for force/pressure generation during breathing, but it is also involved in other non-ventilatory expulsive behaviors. This review considers alterations in diaphragm muscle fiber types and the neural control of the diaphragm across our lifespan and in various disease conditions.