Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Wudhikarn, Kitsada; Bunworasate, Udomsak; Julamanee, Jakrawadee; Lekhakula, Arnuparp; Ekwattanakit, Supachai; Khuhapinant, Archrob; Chuncharunee, Suporn; Niparuck, Pimjai; Numbenjapon, Tontanai; Prayongratana, Kannadit; Kanitsap, Nonglak; Wongkhantee, Somchai; Makruasi, Nisa; Wong, Peerapon; Norasetthada, Lalita; Nawarawong, Weerasak; Sirijerachai, Chittima; Chansung, Kanchana; Suwanban, Tawatchai; Praditsuktavorn, Pannee; Intragumtornchai, Tanin
• Is Part Of: Journal of geriatric oncology. Volume 11:Issue 1(2020)
• Page Start: 62
• Page End: 68
• Publication Date: 2020-01
• Subjects: Peripheral T cell lymphoma -- Natural killer/T cell lymphoma -- Older patients -- Chemotherapy; Geriatric oncology -- Periodicals; Neoplasms -- Periodicals; Aged -- Periodicals; Geriatric oncology; Electronic journals; Periodicals; 618.976994005
• DOI: 10.1016/j.jgo.2019.03.016
• Languages: English
• ISSNs: 1879-4068

Abstract

Abstract: Introduction: Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups. Methods: We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60 years old from Thailand nationwide multicenter registry. Results: Of 127 patients, median age of diagnosis was 67 years old. Patients aged older than 75 years old had similar characteristics to younger (60–74 years old) but higher comorbidity index. Seventy-nine patients (62.2%) received intensive/definite multi-agent chemotherapy, however, the proportion was significant lower in older patients (70.4% vs 34.5%, p < .001). After a median follow up duration of 17.3 months, 2-year progression free survival and overall survival were 38.1% and 48.5%. Univariate and multivariable analysis demonstrated older age, poor performance status and absence of definite multi-agent chemotherapy were associated with inferior survival. Definite multi-agent lymphoma specific chemotherapy was an independent factor for overall survival after adjustment for age, comorbidity index, performance status and prognostic index for T cell lymphoma. Conclusion: Despite overall poor prognosis of PTCL and NKTCL in older adults, chemotherapy could result in objective response and long-term survival in selected patients of this vulnerable age group thus emphasizing the importance of comprehensive geriatric evaluation.