Associations between Turning Characteristics and Corticospinal Inhibition in Young and Older Adults. (15th January 2020)

• Record Type: Journal Article
• Authors: Swanson, Clayton W.; Fling, Brett W.
• Is Part Of: Neuroscience. Volume 425(2020)
• Page Start: 59
• Page End: 67
• Publication Date: 2020-01-15
• Subjects: cSP cortical silent period -- GABA gamma-aminobutyric acid -- MEPs motor evoked potentials -- MVC maximal voluntary contractions -- OA older adults -- TMS transcranial magnetic stimulation -- VMO vastus medialis oblique -- YA young; aging -- turning -- cortical silent period -- TMS -- wearable sensors -- inhibition; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2019.10.051
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Highlights: 42% of falls occur during transfers or body weight shifts such as turning. Older adults had reduced turning performance compared to young adults. Older adults demonstrated less inhibition in the right motor cortex compared to the left. Older adults who maintained motor cortex inhibition performed turns similar to young adults. These findings lend support to a right hemispheric model of aging. Abstract: The effects of aging are multifaceted including deleterious changes to the structure and function of the nervous system which often results in reduced mobility and quality of life. Turning while walking (dynamic) and in-place (stable) are ubiquitous aspects of mobility and have substantial consequences if performed poorly. Further, turning is thought to require higher cortical control compared to bouts of straight-ahead walking. This study sought to understand how relative amounts of corticospinal inhibition as measured by transcranial magnetic stimulation and the cortical silent period within the primary motor cortices are associated with various turning characteristics in neurotypical young (YA) and older adults (OA). In the current study, OA had reduced peak turn velocity and increased turn duration for both dynamic and stable turns. Further, OA demonstrated significantly reduced corticospinal inhibition within the right motor cortex. Finally, all associations between corticospinal inhibition and turning performance were specific to the right hemisphere, reflecting that those OA who maintained high levels of inhibition performed turning similar to their younger counterparts. These results compliment the right hemisphere model of aging and lateralization specification of cortically regulated temporal measures of dynamic movement. While additional investigations are required, these pilot findings provide an additional understanding as to the neural control of dynamic movements.