Addressing frailty in patients with breast cancer: A review of the literature. Issue 1 (January 2020)

• Record Type: Journal Article
• Authors: Jauhari, Yasmin; Gannon, Melissa Ruth; Dodwell, David; Horgan, Kieran; Tsang, Carmen; Clements, Karen; Medina, Jibby; Tang, Sarah; Pettengell, Ruth; Cromwell, David Alan
• Is Part Of: European journal of surgical oncology. Volume 46:Issue 1(2020)
• Page Start: 24
• Page End: 32
• Publication Date: 2020-01
• Subjects: Frailty -- Breast cancer -- Elderly -- Review; BCS breast conserving surgery -- CGA comprehensive geriatric assessment -- EUSOMA European Society of Breast Cancer Specialists -- ER oestrogen receptor -- MDT multi-disciplinary team -- NABCOP National Audit of breast cancer in older patients -- PET primary endocrine therapy -- SIOG International Society of Geriatric Oncology; Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2019.08.011
• Languages: English
• ISSNs: 0748-7983

Abstract

Abstract: Various studies have documented variation in the management of older patients with breast cancer, and some of this variation stems from different approaches to balancing the expected benefit of different treatments, with the ability of patients to tolerate them. Frailty is an emerging concept that can help to make clinical decisions for older patients more consistent, not least by providing a measure of 'biological' ageing. This would reduce reliance on 'chronological' age, which is not a reliable guide for decisions on the appropriate breast cancer care for older patients. This article examines the potential of frailty assessment to inform on breast cancer treatments. Overall, the current evidence highlights various benefits from implementing comprehensive geriatric assessment and screening for frailty in breast cancer patients. This includes a role in supporting the selection of appropriate therapies and improving physical fitness prior to treatment. However, there are challenges in implementing routine frailty assessments in a breast cancer service. Studies have used a diverse array of frailty assessment instruments, which hampers the generalisability of research findings. Consequently, a number of issues need to be addressed to clearly establish the optimal timing of frailty assessment and the role of geriatric medicine specialists in the breast cancer care pathway.