Spotlight on epigenetic reprogramming in cardiac regeneration. (January 2020)

• Record Type: Journal Article
• Authors: Soler-Botija, Carolina; Forcales, Sonia Vanina; Bayés Genís, Antoni
• Is Part Of: Seminars in cell & developmental biology. Volume 97(2020)
• Page Start: 26
• Page End: 37
• Publication Date: 2020-01
• Subjects: Myocardial infarction -- Cardiac regeneration -- Epigenetic -- Chromatin dynamics -- microRNA -- Methylation -- Deacetylation; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2019.04.009
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: Heart failure of ischemic origin is caused by the presence of a large scar resulting from an acute myocardial infarction. Acute myocardial infarction generally occurs when blood supply to the heart is blocked. Regenerative strategies that limit infarct injury would be able to prevent adverse post-ischemic remodelling and maintain the structural support necessary for effective cardiomyocyte contraction. Our understanding of endogenous cardiac regeneration and its biology has exposed a variety of targets for therapeutic approaches, such as non-coding RNAs, DNA methylation, histone modifications, direct cardiac reprogramming, cell transplantation, stimulation of resident cardiomyocytes, proliferation, and inhibition of cardiomyocyte death. In this review, we address the epigenetic mechanisms underlying these strategies and the use of therapeutic epigenetic molecules or epidrugs.