Recyclable menthol-based deep eutectic solvent micellar system for extracting phytochemicals from Ginkgo biloba leaves. (20th January 2020)

• Record Type: Journal Article
• Authors: Wang, Li-Tao; Yang, Qing; Cui, Qi; Fan, Xiao-Hong; Dong, Ming-Zhu; Gao, Ming-Zhu; Lv, Mu-Jie; An, Juan-Yan; Meng, Dong; Zhao, Xiu-Hua; Fu, Yu-Jie
• Is Part Of: Journal of cleaner production. Volume 244(2020)
• Publication Date: 2020-01-20
• Subjects: Ginkgo biloba L. leaves -- Green extraction -- Two-phase menthol-based aqueous deep eutectic solvent -- Phytochemicals -- Recycling -- Extraction mechanism; AA Acetic acid -- AIM Atoms in molecules -- ANOVA Analysis of variance -- BA Butyric acid -- BBD Box-Behnken design -- DES Deep eutectic solvent -- DFT Density functional theory -- FA Formic acid -- GBE Ginkgo biloba extract -- HA Hexanoic acid -- HBA Hydrogen-bond acceptor -- HBD Hydrogen bond donor -- LA Lactic acid -- ND Not determined -- OA Octanoic acid -- PA Propionic acid -- RDG Reduced density gradient -- RSM Response surface methodology -- LAA Levulinic acid -- UHPLC–MS/MS Ultra performance liquid chromatography–tandem mass spectrometer; Factory and trade waste -- Management -- Periodicals; Manufactures -- Environmental aspects -- Periodicals; Déchets industriels -- Gestion -- Périodiques; Usines -- Aspect de l'environnement -- Périodiques; 628.5
• DOI: 10.1016/j.jclepro.2019.118648
• Languages: English
• ISSNs: 0959-6526

Abstract

Abstract: With an emphasis on human health, the demand for natural products is progressively increasing and sustainable extraction technologies for phytochemicals are receiving greater attention. In the present study, we established a naturally recyclable two-phase aqueous micellar system comprising menthol-based hydrophobic deep eutectic solvent (DES) in water. Typical representative phytochemicals from Ginkgo biloba leaves included flavonoid glycosides, terpene lactones, and bioflavonoids. These compounds have differing polarities and were selected as targets for the evaluation of our novel menthol-based aqueous DES as a green and sustainable extraction technology for partitioning various compounds. Components of the aqueous DES system and extraction process were systematically studied, and the following optimal conditions were identified: menthol–acetic acid ratio of 1:1 (mol/mol), DES–water ratio of 1:1 (v/v), solid–liquid ratio of 15:1 (mg/mL), extraction power of 200 W, and extraction time of 10 min. The two-phase system easily separated compounds with differing polarity into the upper (DES-rich phase) and lower (water phase) phases after extraction. Analyses of the related mechanisms indicated that micelle formation of menthol-based DES in water was the dominant separating process and that this process provided large contact areas between target compounds and extraction solvent, thereby promoting extraction from G. biloba leaves. Moreover, this aqueous DES system could efficiently be recovered and reused in regeneration studies. This novel menthol-based aqueous DES system provides a sustainable extraction technology for various phytochemicals from plant materials. Highlights: The micellar system showed superior extraction yields to conventional solvents. The micellar system can extract and separate compounds with different polarities. The system can be recovered and reused easily. Natural micellar system is green alternative for phytochemicals extraction.