Antitumor Therapeutics: A Virus‐Mimicking pH‐Responsive Acetalated Dextran‐Based Membrane‐Active Polymeric Nanoparticle for Intracellular Delivery of Antitumor Therapeutics (Adv. Funct. Mater. 51/2019). (17th December 2019)

• Record Type: Journal Article
• Authors: Wannasarit, Saowanee; Wang, Shiqi; Figueiredo, Patrícia; Trujillo, Claudia; Eburnea, Francesca; Simón‐Gracia, Lorena; Correia, Alexandra; Ding, Yaping; Teesalu, Tambet; Liu, Dongfei; Wiwattanapatapee, Ruedeekorn; Santos, Hélder A.; Li, Wei
• Is Part Of: Advanced functional materials. Volume 29:Number 51(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-12-17
• Subjects: drug delivery -- endosomal escape -- microfluidics -- pH‐responsive -- polymer nanoparticles; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201970351
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : In article number 1905352, Shiqi Wang, Hélder A. Santos, Wei Li, and co‐workers report a virus‐mimicking polymeric nanoparticle with endosomolytic activity and pH‐responsive drug release properties. With great drug encapsulation efficiency, in vitro therapeutic efficacy, and oncolytic activity towards 3D tumor spheroids after conjugating tumor penetrating peptides, this nanoparticle shows promising potential for the intracellular delivery of antitumor therapeutics.