The effect of nonpharmacologic therapy on global cognitive functions in patients with Alzheimer's disease: an updated meta-analysis of randomized controlled trials. (2nd January 2020)

• Record Type: Journal Article
• Authors: Wei, Shouchao; Mai, Yingren; Peng, Wanjuan; Ma, Jing; Sun, Chaowen; Li, Guangning; Liu, Zhou
• Is Part Of: International journal of neuroscience. Volume 130:Number 1(2020)
• Page Start: 28
• Page End: 44
• Publication Date: 2020-01-02
• Subjects: Nonpharmacologic therapy -- global cognition functions -- Alzheimer's disease -- systematic review -- meta-analysis; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2019.1638377
• Languages: English
• ISSNs: 0020-7454

Abstract

Abstract: Background: The effectiveness of non-pharmacologic therapy (NPT) in treating the global cognition dysfunction associated with Alzheimer's disease (AD) has not been clearly demonstrated. Therefore, we performed a meta-analysis to address this issue. Methods: The Cochrane Central Register of Controlled Trials, PUBMED, EMBASE and other databases were searched, and outcomes measured by the Mini-Mental State Examination (MMSE) or the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) were analysed. Results: Seven types of NPT were included, 25 randomized controlled trials (RCTs) were selected and 3238 participants were included in the meta-analysis. There were significant differences between the NPT and control groups in the MMSE and ADAS-cog scores. Conclusions: Although more extensive trials need to be performed, NPT has been observed to be beneficial in AD patients.