Two unusual cases of lacrimal sac inflammatory polyps with allergic mucin sine fungi. (2nd January 2020)

• Record Type: Journal Article
• Authors: Haq, Imran; Mudhar, Hardeep Singh; Currie, Zanna; Mirza, Showkat; Salvi, Sachin
• Is Part Of: Orbit. Volume 39:Number 1(2020)
• Page Start: 53
• Page End: 60
• Publication Date: 2020-01-02
• Subjects: Allergic mucin -- IgG4 -- inflammatory polyp -- lacrimal sac; Eye-sockets -- Surgery -- Periodicals; Eye-sockets -- Diseases -- Periodicals; Orbit -- surgery -- Periodicals; Orbital Diseases -- Periodicals; 617.7
• DOI: 10.1080/01676830.2019.1579844
• Languages: English
• ISSNs: 0167-6830

Abstract

ABSTRACT: This case report deals with two patients with lacrimal sac swellings. Case 1 presented with bilateral sac swelling and Case 2 with a unilateral presentation. Dacrocystorhinostomy (DCR) followed by biopsies of both sacs in Case 1 revealed inflammatory polyps of the sac mucosa, identical in appearance to typical nasal allergic inflammatory polyps. The biopsies were accompanied by typical allergic mucin, featuring tiered mucin layers between which were numerous eosinophils, accompanied by Charcot–Leyden crystals. The histology of the dacryocystectomy specimen for Case 2 showed identical histopathological changes with the additional feature of prominent numbers of Immunoglobulin G (IgG)4-positive plasma cells in the stroma of the lacrimal sac inflammatory polyps. These features extend the sites affected by allergic inflammatory polyps and allergic mucin and possible pathogenesis is discussed.