Disease-related proteins determination based on surface-enhanced Raman spectroscopy. Issue 10 (26th November 2019)

• Record Type: Journal Article
• Authors: Yang, Bo; Jin, Sila; Wang, Ye; Bao, Huiwei; Sun, Jingmeng; Chen, Lei; Chung, Hoeil; Jung, Young Mee
• Is Part Of: Applied spectroscopy reviews. Volume 54:Issue 10(2019)
• Page Start: 856
• Page End: 872
• Publication Date: 2019-11-26
• Subjects: Surface-enhanced Raman spectroscopy (SERS) -- disease-related proteins -- SERS-based bioassay -- protein determination -- early disease diagnosis; Spectrum analysis -- Periodicals; 535.84
• DOI: 10.1080/05704928.2018.1557676
• Languages: English
• ISSNs: 0570-4928

Abstract

Abstract: Surface-enhanced Raman spectroscopy (SERS) is a promising platform for simple, rapid, and economical protein quantitation and analysis and can achieve much lower detection limits for the ultrasensitive detection of proteins and a much wider linear concentration range for quantitative analysis than other methods can. In addition, SERS can provide a large amount of fingerprint information for the individual components of a mixture through SERS effects, which are sensitive and selective for different types of proteins and protein mixtures. In general, the occurrence and development of diseases are accompanied by changes in the content or structure of biomarkers (disease-related proteins). Here, we provide an overview of the SERS technique and its applications to disease-related protein determination. Different diseases, such as Alzheimer's disease (AD), cardiac muscle tissue injury, and multicancer, are discussed and exhibit potential utility in biomarker detection and diagnosis. SERS opens a new path to the early diagnosis of critical diseases, which will effectively reduce human suffering and mortality.