Leptin/adiponectin ratio correlates with hepatic steatosis but not arterial stiffness in nonalcoholic fatty liver disease in Japanese population. (February 2020)

• Record Type: Journal Article
• Authors: Mikami, Kenichiro; Endo, Tetsu; Sawada, Naoya; Igarashi, Go; Kimura, Masayo; Hasegawa, Takuma; Iino, Chikara; Tomita, Hirofumi; Sawada, Kaori; Nakaji, Shigeyuki; Matsuzaka, Masashi; Torok, Natalie J.; Fukuda, Shinsaku
• Is Part Of: Cytokine. Volume 126(2020)
• Publication Date: 2020-02
• Subjects: Leptin -- Adiponectin -- Nonalcoholic fatty liver disease -- Arterial stiffness -- Interleukin-6 -- Brief-type self-administered diet history questionnaire; NAFLD nonalcoholic fatty liver disease -- CVD cardiovascular disease -- BMI body mass index -- BFP body fat percentage -- BaPWV brachial-ankle pulse wave velocity -- L/A leptin-to-adiponectin -- BDHQ brief-type self-administered diet history questionnaire -- AST aspartate aminotransferase -- ALT alanine aminotransferase -- HDL high-density lipoprotein -- LDL low-density lipoprotein -- GGT gamma-glutamyl-transpeptidase -- IL-6 interleukin-6 -- IL-17 interleukin-17; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2019.154927
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Leptin-to-adiponectin (L/A) ratio correlated with hepatic steatosis in NAFLD. Arterial stiffness correlated strongly with age, and weakly with hepatic steatosis. Arterial stiffness was not correlated with L/A ratio in NAFLD. Interleukin-6 correlated with arterial stiffness, and very weakly with L/A ratio. L/A ratio correlated with triglycerides and the ratio of total cholesterol to HDL-cholesterol. Abstract: Background and aims: Cardiovascular disease (CVD) is a leading cause of mortality in nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the relationship of leptin-to-adiponectin (L/A) ratio with hepatic steatosis and arterial stiffness in NAFLD. Methods: The subjects were 871 Japanese adults who participated in a health survey. Dietary intake, body composition, lipid profile, serum interleukin-6 (IL-6), leptin, and adiponectin were analyzed. NAFLD was defined as fatty liver on ultrasonography in the absence of other causes of steatosis. Arterial stiffness was evaluated by the brachial-ankle pulse wave velocity (baPWV). Results: The subjects with NAFLD had a greater body mass index (BMI) and body fat percentage (BFP); a higher intake of daily energy (kcal) and carbohydrates; and a higher prevalence of hypertension, diabetes, and hyperlipidemia. The subjects with NAFLD had higher serum leptin and lower serum adiponectin concentrations and a higher L/A ratio than subjects without NAFLD. The L/A ratio increased with increasing severity of steatosis. The L/A ratio showed positive correlations with BMI and BFP, and a negative correlation with age. Women had higher L/A ratio and BFP levels than men regardless of the presence or absence of NAFLD. There was a weak positive correlation between baPWV and severity of steatosis. BaPWV was strongly correlated with age, while no relation was found between baPWV and L/A ratio. IL-6 level was correlated with baPVW and age, while the correlation between Il and 6 level and L/A ratio was very weak. The L/A ratio was correlated with triglycerides and the ratio of total cholesterol to high-density lipoprotein-cholesterol. Conclusion: L/A ratio and arterial stiffness were associated with the severity of steatosis, whereas there was no correlation between L/A ratio and arterial stiffness in NAFLD. These findings suggest that not only leptin and adiponectin but also other factors might be involved in the pathogenesis for atherosclerosis in NAFLD.