Metronidazole-induced Encephalopathy. (2019)

• Record Type: Journal Article
• Authors: Phyu, Htay; Edmond, Michael B.; Kobayashi, Takaaki
• Is Part Of: IDCases. Volume 18(2019)
• Publication Date: 2019
• Subjects: Metronidazole -- Encephalopathy; Communicable diseases -- Periodicals; Communicable Diseases -- Case Reports; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1016/j.idcr.2019.e00639
• Languages: English
• ISSNs: 2214-2509

Abstract

Abstract: Metronidazole is commonly used in the treatment of anaerobic infections. While neuropathy is known to be associated with metronidazole, encephalopathy has been rarely reported. We herein present a case of metronidazole-induced encephalopathy presenting as frequent falls and slurred speech. Magnetic resonance imaging of the brain demonstrated T2/FLAIR hyperintensity in the dentate nuclei bilaterally. Soon after the discontinuation of metronidazole, dysarthria and dysmetria resolved. Metronidazole-induced encephalopathy should be considered in patients presenting with new neurologic symptoms after the initiation of metronidazole.