Essential role of autophagy in resource allocation during sexual reproduction. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Gao, Hui; Khawar, Muhammad Babar; Li, Wei
• Is Part Of: Autophagy. Volume 16:Issue 1(2020)
• Page Start: 18
• Page End: 27
• Publication Date: 2020-01-02
• Subjects: Autophagy -- embryogenesis -- gametogenesis -- resource allocation -- sexual reproduction; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2019.1628543
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensable for spermatogenesis and oogenesis, and it participates in early embryonic development and maternal-fetus crosstalk to ensure the development of embryos or fetuses. Thus, autophagy provides the molecular basis for resource allocation among parents and their offspring, providing an important way to benefit the next generation. Abbreviations : ATG: autophagy-related; Becn1 : beclin 1, autophagy related; CMA: chaperone-mediated autophagy; epg : ectopic PGL granules; ES: ectoplasmic specialization; EVTs: extravillous trophoblasts; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PCD: programmed cell death; PTB: preterm birth; STB: syncytiotrophoblast