Identification of an AGO (Argonaute) protein as a prey of TER94/VCP. Issue 1 (2nd January 2020)

• Record Type: Journal Article
• Authors: Kobayashi, Hotaka; Tomari, Yukihide
• Is Part Of: Autophagy. Volume 16:Issue 1(2020)
• Page Start: 190
• Page End: 192
• Publication Date: 2020-01-02
• Subjects: Argonaute -- gene silencing -- Iruka -- microRNA -- ubiquitin -- Ufd1–Npl4 -- VCP; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2019.1691351
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: VCP (valosin containing protein) recognizes a wide variety of substrates and mediates their degradation via the ubiquitin-proteasome system and macroautophagy/autophagy. The substrate repertoire of VCP, however, is not fully understood. In our recent study, we found that Drosophila TER94/VCP mediates autophagic degradation of an Argonaute subfamily protein (AGO1), which binds microRNAs (miRNAs) and silences the expression of thousands of target genes. In the absence of TER94/VCP, miRNA-mediated gene silencing is globally impaired. Our findings reveal an unexpected connection between VCP and AGO, which may dramatically expand the biological significance of VCP.