Prognostic and predictive factors on overall survival and surgical outcomes in pancreatic neuroendocrine tumors: recent advances and controversies. Issue 12 (2nd December 2019)

• Record Type: Journal Article
• Authors: Lee, Lingaku; Ito, Tetsuhide; Jensen, Robert T
• Is Part Of: Expert review of anticancer therapy. Volume 19:Issue 12(2019)
• Page Start: 1029
• Page End: 1050
• Publication Date: 2019-12-02
• Subjects: Pancreatic neuroendocrine neoplasms -- prognostic factor -- biomarker -- molecular marker -- pathological factor -- surgical resection; Cancer -- Treatment -- Periodicals; 616.99406
• DOI: 10.1080/14737140.2019.1693893
• Languages: English
• ISSNs: 1473-7140

Abstract

ABSTRACT: Introduction : Recent advances in diagnostic modalities and therapeutic agents have raised the importance of prognostic factors in predicting overall survival, as well as predictive factors for surgical outcomes, in tailoring therapeutic strategies of patients with pancreatic neuroendocrine neoplasms (panNENs). Areas covered : Numerous recent studies of panNEN patients report the prognostic values of a number of clinically related factors (clinical, laboratory, imaging, treatment-related factors), pathological factors (histological, classification, grading) and molecular factors on long-term survival. In addition, an increasing number of studies showed the usefulness of various factors, specifically biomarkers and molecular makers, in predicting recurrence and mortality related to surgical treatment. Recent findings (from the last 3 years) in each of these areas, as well as recent controversies, are reviewed. Expert commentary : The clinical importance of prognostic and predictive factors for panNENs is markedly increased for both overall outcome and post resection, as a result of recent advances in all aspects of the diagnosis, management and treatment of panNENs. Despite the proven prognostic utility of routinely used tumor grading/classification and staging systems, further studies are required to establish these novel prognostic factors to support their routine clinical use.