Cover Feature: Convenient Approach to 2‐Substituted (Thio)morpholin‐3‐ones from α‐Diazoacetates via X‐H Carbene Insertion – Lactamization Sequence (Eur. J. Org. Chem. 45/2019). Issue 45 (26th November 2019)

• Record Type: Journal Article
• Authors: Solovyov, Igor; Dar'in, Dmitry; Krasavin, Mikhail
• Is Part Of: European journal of organic chemistry. Issue 45(2019)
• Page Start: 7400
• Page End: 7400
• Publication Date: 2019-11-26
• Subjects: Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201901632
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract : The Cover Feature shows the new convenient way of assembling medicinally important morpholinones and thiomorpholinones by reacting α‐diazo acetate esters with amino alcohols and amino thiols. The reaction involves RhII‐catalyzed O–H or S–H carbene insertion followed by lactamization. More information can be found in the Full Paper by M. Krasavin et al.