Coronary Artery Calcification Score as a Predictor of All-Cause Mortality and Cardiovascular Outcome in Peritoneal Dialysis Patients. Issue 2 (March 2016)

• Record Type: Journal Article
• Authors: Xie, Qionghong; Ge, Xiaolin; Shang, Da; Li, Yun; Yan, Huanqing; Tian, Jing; Hao, Chuan-Ming; Zhu, Tongying
• Is Part Of: Peritoneal dialysis international. Volume 36:Issue 2(2016)
• Page Start: 163
• Page End: 170
• Publication Date: 2016-03
• Subjects: Coronary artery calcification -- all-cause mortality -- cardiovascular events -- cardiovascular mortality -- risk factor; Peritoneal dialysis -- Periodicals; Continuous ambulatory peritoneal dialysis -- Periodicals; 617.461059
• DOI: 10.3747/pdi.2014.00124
• Languages: English
• ISSNs: 0896-8608

Abstract

Background: This study aimed to examine whether the coronary artery calcification score (CaCS) was associated with the prognosis of peritoneal dialysis (PD) patients. Methods: Adult PD patients who were clinically stable for at least 2 months were recruited for this prospective, observational cohort study. Coronary artery calcification was assessed using multislice spiral computed tomography and was recorded according to the Agatston score. The end-points including all-cause mortality, cardiovascular events, and cardiovascular mortality were assessed. Multivariate Cox regression was used to identify independent predictors of all-cause mortality, cardiovascular events (CVEs), and cardiovascular mortality. Results: A total of 179 PD patients (86 men) with a mean age of 63.5 ± 14.8 years were recruited for this study. Coronary artery calcification scores ranging from 0 to 5, 257 were stratified as follows: no (CaCS = 0, n = 54), low (0 < CaCS < 400, n = 72), and high (CaCS ≥ 400, n = 53) calcification. The follow-up duration was 30.6 ± 16.2 (24 – 63) months. Compared with the no calcification group, patients with a higher CaCS were older and had lower diastolic blood pressure, residual renal function, and serum albumin, and higher HbA1 C and serum insulin. Multivariate Cox regression revealed that the CaCS was an independent predictor for all the 3 endpoints after adjustment in PD patients. Conclusions: CaCS was an independent predictor of all-cause mortality, cardiovascular events, and cardiovascular mortality in patients receiving peritoneal dialysis.