Gellan gum-based delivery systems of therapeutic agents and cells. (1st February 2020)

• Record Type: Journal Article
• Authors: Palumbo, Fabio Salvatore; Federico, Salvatore; Pitarresi, Giovanna; Fiorica, Calogero; Giammona, Gaetano
• Is Part Of: Carbohydrate polymers. Volume 229(2020)
• Publication Date: 2020-02-01
• Subjects: BAG bioactive glass -- BAG-OM bioactive glass osteogenic medium extracts -- BMP-2 bone morphogenic-protein 2 -- CaP calcium phosphate -- CM-GG carboxymethyl gellan gum -- DDS drug delivery systems -- ECM extracellular matrix -- EDS energy dispersive spectroscopy -- FDA Food and Drug Administration -- GG gellan gum -- GG-Cin gellan gum-cinnamate -- GG-MA methacrylated gellan gum -- GG-Mal gellan gum- maleate -- GG-GMA glycidyl-methacrylated gellan gum -- GG-Tc gellan gum-thioglycolate -- Glc glucose -- Gly glycerol -- HA hyaluronic acid -- haGG high acyl gellan gum -- hASCs human adipose stem cells -- HAp hydroxyapatite -- hDMECSs human dermal microvascular endothelial cells -- hESCs human embryonic stem cells -- hKCs human keratinocytes -- HNTs hallosyte nanotubes -- hPSCs human-induced pluripotent stem cells -- IFP-SCs infrapatellar fat pad-derived stem cells -- IPN interpenetrating polymer network -- IV intervertebral -- laGG low acyl gellan gum -- LAOS large Amplitude Oscillatory Shear -- LDL low-density lipoprotein -- MSCs mesenchymal stem cells -- MC3T3-E1 mouse osteoblastic cells -- MTX methotrexate -- NCs nasal chondrocytes -- NHDF-NEO neonatal normal human dermal fibroblast -- nGG native gellan gum -- NHS N-Hydroxysuccinimide -- OECs olfactory ensheathing cells -- OM osteogenic medium -- PANi polyaniline -- PBS phosphate buffer solution -- PCL polycaprolactone -- PEG poly(ethylene glycol) -- PEGDA poly(ethylene glycol)-diacrylate -- PEGDMA poly(ethylene glycol)-dimethylacrylate -- PLGA poly(lactic-co-glycolic acid) -- PVA poly(vinyl alcohol) -- Rha rhamnose -- S-GG thiolated gellan gum -- SaOS-2 human osteoblast-like cells -- SPD spermidine trihydrochloride -- SPM spermine tetrahydrochloride -- TERM tissue engineering and regenerative medicine -- TGF- 3 transforming growth factor-β3 -- Tm transition coil-helix -- VEGF vascular endothelial growth factor -- XRD X-ray powder diffraction -- μCT micro-computed tomography; Gellan Gum -- drug delivery -- cell therapy; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2019.115430
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: The purpose of this review is to make a summary of high quality research trends using gellan gum (GG) as a polymeric constituent for the design of innovative drug delivery systems and devices for biomedical applications, such as cell therapy and regenerative medicine. The use of gellan gum is described both in its native form and as chemically functionalized derivatives or physically mixed with natural or synthetic materials. Starting from a systematic study of recent research works, the main properties of the native polysaccharide have been highlighted and therefore some improvements have been focused thanks to the design of chemically functionalized derivatives and the use of composite materials.