Fabrication of Curcumin‐Modified TiO2 Nanoarrays via Cyclodextrin Based Polymer Functional Coatings for Osteosarcoma Therapy. Issue 23 (30th October 2019) - Zhang, Meng
Abstract: The incomplete removal of bone tumors leads to increased local recurrence and poor prognosis. To prevent ostoperative tumor recurrence and simultaneously repair surgery‐caused bone defects, there is a need of great significance to develop implantable biomaterials possessing both cancer cell‐killing ability and excellent bioactivity. In this work, a functionalized titanium‐based implant is successfully fabricated by loading curcumin (CUR) onto cyclodextrin based polymer (pCD) modified titanium dioxide (TiO2 ) nanorod arrays. Herein, a polydopamine (pDA) assisted film is implemented as a first coating layer onto the surface of the TiO2 nanoarrays to guarantee the robust anchorage of the pCD. The pCD coating acts as a reservoir for CUR, allowing for efficient drug loading and sustained release of anticancer drugs. Studies show that the CUR‐modified surfaces (TiO2 /pDA/pCD/CUR) can significantly promote apoptosis of osteosarcoma cells in vitro by inducing mitochondrial dysfunction caused by the ROS overproduction, and meanwhile, effectively inhibit the tumor growth in vivo. Moreover, such functionalized implants with surface density of loaded CUR at 22.48 µg cm −2 or lower support the attachment and proliferation of osteoblasts in vitro. These results successfully demonstrate that as‐prepared TiO2 /pDA/pCD/CUR constructs have combined anticancer performance and good biocompatibility, which has great promise for the surgical therapy of bone tumors. Abstract : An original curcumin loaded TiO2 nanoarray construct is successfully fabricated through cyclodextrin based polymer acting as a drug reservoir. The results of biological assays indicate that the curcumin‐modified Ti‐based construct has combined anticancer performance and good biocompatibility, which can effectively inhibit the growth of osteosarcoma in vitro and in vivo, and simultaneously promote the attachment and proliferation of osteoblasts.