OP131 Rapid Review For Policy: Interchangeability Of Biological Medicines. (2019)

• Record Type: Journal Article
• Authors: Rego, Daniela; Farinasso, Cecilia; Silva, Roberta Borges; Gomes, Dalila Fernandes; de Aguiar, Aurelina Aguiar; Leão, Luciana Simões Camara; Sachetti, Camile Giaretta; Gonçalves, Lenilson Pereira; Leite, Betânia
• Is Part Of: International journal of technology assessment in health care. Volume 35(2019)Supplement 1
• Page Start: 30
• Page End: 30
• Publication Date: 2019
• Subjects: Medical technology -- Periodicals; Technology assessment -- Periodicals; 610.28
• DOI: 10.1017/S0266462319001612
• Languages: English
• ISSNs: 0266-4623

Abstract

Abstract : Introduction: Due to the high judicialization rates which pressure the financing of biologic medicines by the Brazilian Unified Health System (Sistema Único de Saúde - SUS), it has been decided to formulate the National Policy for Biologic Medicines. After identification of problems and prioritization, interchangeability based only on economic criteria was the main problem to be confronted. The primary objective of this study was to identify political options to approach the problem of interchangeability in systematic reviews. Methods: We conducted a rapid evidence synthesis for policy based on an adaptation of the SUPPORT tools, and searched in six literature databases. The selection of studies was performed in a systematic, transparent and independent manner. The International Network of Agencies in Health Technology Assessment (INAHTA) members were consulted to learn how this practice occurs worldwide. Results: We included seven systematic reviews and one policy brief, whose options to approach the problem were: production of robust scientific evidence on interchangeability; implementation of a pharmacovigilance system; appreciation of the clinical efficacy in the practice of interchangeability; and educational strategies for healthcare professionals in Brazil. Nine countries responded to our query. Conclusions: Evidence-informed policy has a central role for the Brazilian Ministry of Health. The present rapid evidence synthesis for policy will subsidize decision making regarding the interchangeability of biologic medicines within the Brazilian Unified Health System.