A low-cost, open-source Turbidostat design for in-vivo control experiments in Synthetic Biology. Issue 26 (2019)

• Record Type: Journal Article
• Authors: Guarino, Agostino; Shannon, Barbara; Marucci, Lucia; Grierson, Claire; Savery, Nigel; di Bernardo, Mario
• Is Part Of: IFAC-PapersOnLine. Volume 52:Issue 26(2019)
• Page Start: 244
• Page End: 248
• Publication Date: 2019
• Subjects: Bio Control -- Biotechnology -- Control System Design -- Machine Design -- Synthetic Biology; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2019.12.265
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: Continuous culture platforms are required to characterise the dynamics of new engineered systems in synthetic biology. In this paper, we review existing turbidostat platforms before describing the design and implementation of our new flexible and low-cost turbidostat for in-vivo control experiments. We provide preliminary experimental results on controlling the optical density of a bacterial culture. We also discuss the potential extensions to our design for the development of in-vivo multicellular control experiments.