Simulation of Intracellular Calcium Release in Heart Cells. Issue 26 (2019)

• Record Type: Journal Article
• Authors: Vysma, Morris; Welsh, James; Laver, Derek
• Is Part Of: IFAC-PapersOnLine. Volume 52:Issue 26(2019)
• Page Start: 238
• Page End: 243
• Publication Date: 2019
• Subjects: Nonlinear systems -- biomedical systems -- parallel processing -- computer simulation; Automatic control -- Periodicals; 629.805
• DOI: 10.1016/j.ifacol.2019.12.264
• Languages: English
• ISSNs: 2405-8963

Abstract

Abstract: Cyclic calcium release and uptake in heart cells has an important role in heart rhythm and contraction, and it is known that the malregulation of calcium release is a predictor for cardiac arrhythmia. A model of this calcium release process was proposed, which consists of a large number of discrete calcium release sites, each involving stiff, stochastic, and nonlinear systems. In this paper we have developed a simulation of this calcium release model, which is parallel across the problem. The simulation is developed in a CUDA framework to be solved using GPUs. Computational efficiency is enhanced by using a DIIRK solver and taking advantage of the sparsity of the Jacobian. The output is shown to display behaviour similar to empirical observations, in particular displaying behaviour known as calcium waves.